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Marfan syndrome is an autosomal dominant connective tissue disorder caused by mutation in the FBN1 gene on chromosome 15. Common features: Tall thin body habitus Long limbs Arachnodactyly Lens subluxation Mitral valve prolapse Aortic aneurysm The most dangerous complication is aortic dissection/rupture. Mnemonic: MARFANS M → Mitral valve ...
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