Thorax

Knowing when to stop: the challenge of macrolide discontinuation in chronic airways disease

Macrolide therapy is an established and effective treatment for selected patients with chronic obstructive airways diseases ...
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Introduction and methods: British Thoracic Society pleural disease guideline 2010

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be ...
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Targeting fatigue in COPD with chronic respiratory failure undergoing pulmonary rehabilitation: a multicentre, randomised, placebo-controlled trial of L-arginine/liposomal ...

Background Pulmonary rehabilitation (PR) is the cornerstone of non-pharmacological treatment for chronic obstructive pulmonary disease (COPD), yet fatigue often persists despite rehabilitation. We ...
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Mucus plugs in COPD: another reason for not losing weight?

In this issue of Thorax , Martinez-Manzano et al explore the relationship between body mass index (BMI) and mucus plugging on CT, both in patients with COPD spanning GOLD grades 1–4 and smokers ...
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Cost-effectiveness of ambulatory care management of primary spontaneous pneumothorax: an open-label, randomised controlled trial

Background Ambulatory management of primary spontaneous pneumothorax has been shown to reduce initial hospitalisation, but at the expense of increase adverse events. As a result, questions remain ...
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The overlap syndrome of asthma and COPD: what are its features and how important is it?

1 Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, Australia 2 Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia Professor P ...
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Breathing exercises for asthma: a randomised controlled trial

Department of Epidemiology and Public Health, University College London, London, UK Dr M Thomas, Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, ...
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Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis

Background Cystic fibrosis (CF) lung disease is defined by large numbers of neutrophils and associated damaging products in the airway. Delayed neutrophil apoptosis is described in CF although it is ...
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Comparison of the seasonal patterns of asthma identified in general practitioner episodes, hospital admissions, and deaths

BACKGROUND Seasonal variations in asthma are widely recognised. This study was undertaken to investigate the relative differences in seasonal patterns by age as they impact on episodes of care in ...
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Long-term multicentre randomised controlled study of high frequency chest wall oscillation versus positive expiratory pressure mask in cystic fibrosis

1 Division of Paediatric Respirology and Department of Physiotherapy, Cystic Fibrosis Clinic, BC Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada 2 Division ...
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Serotype prevalence in adults hospitalised with pneumococcal non-invasive community-acquired pneumonia

Background The distribution of pneumococcal serotypes implicated in non-invasive community-acquired pneumonia (CAP) in adults is currently unknown. Methods A prospective observational cohort study was ...
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Back to basics: the respiratory management of Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a progressive, ultimately lethal neuromuscular disorder transmitted by X-linked inheritance. In DMD, mutations in the dystrophin gene cause an absence of ...