RMD Open

Early features of cellular ageing impair differentiation capacity in human lymph node fibroblasts prior to rheumatoid arthritis onset

Objective Cellular ageing of the immune system has been suggested to play a role in the pathogenesis of rheumatoid arthritis ...
rmdopen.bmj

RMD Open

is an open access, peer reviewed rheumatology journal that publishes original research on musculoskeletal disorders and rheumatic conditions ...
RMD Open

Risk of cognitive disorders in patients with primary Sjögren’s disease: data from Korean Health Insurance Service

Objective To investigate the risk of incident cognitive disorders in patients with primary Sjögren’s disease (pSjD) using nationwide Korean National Health Insurance Service data.Methods This ...
RMD Open

Early SLE may follow a fast comorbidity/multimorbidity trajectory associated with flare burden and glucocorticoid exposure

Background Patients with systemic lupus erythematosus (SLE) carry a substantial comorbidity load associated with worse prognosis, yet most evidence pertains to long-standing disease. How comorbidities ...
RMD Open

Distinct molecular signature in relapsed patients with ANCA-associated vasculitis

Objectives The pathogenesis of relapses in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) remains ill defined. We aimed to identify whether there are any ...
rmdopen.bmj

Real-world longitudinal assessment of anifrolumab in patients with systemic lupus erythematosus: clinical outcomes, safety and modulation of cytokines and neutrophil activity

Objectives To assess clinical effectiveness, safety and in vivo effects on cytokines, chemokines and low-density neutrophils (LDNs) in patients with active systemic lupus erythematosus (SLE) treated ...
rmdopen.bmj

Dance as a double-edged sword: physiological adaptations, injury risks and therapeutic potential

Dance is a complex physical activity with high biomechanical and artistic demands that cause repetitive stress on the musculoskeletal, neuromuscular, metabolic and cardiorespiratory systems. Dance ...
rmdopen.bmj

Site-specific articular responses to b/tsDMARDs in rheumatoid arthritis: a longitudinal observational study from the Swiss Clinical Quality Management Registry

Objectives Whether treatment response differs across affected joints in rheumatoid arthritis (RA) remains unclear. We sought to determine whether responses to tumour necrosis factor inhibitors (TNFi) ...
rmdopen.bmj

A phase III, randomised, double-blind, multi-dose, placebo- and naproxen-controlled study to evaluate the efficacy and safety of fasinumab in patients with pain due to ...

Background Chronic pain due to osteoarthritis (OA) causes considerable burden, and current treatment options are limited. This phase III study aimed to compare the efficacy and safety of fasinumab, an ...
rmdopen.bmj

Performance in adults of the EULAR/PRINTO/PRES (Ankara 2008) classification criteria for IgA vasculitis

Objective To examine the performance in adults of the European Alliance of Associations for Rheumatology (EULAR)/Pediatric Rheumatology European Society (PReS)-endorsed Ankara 2008 classification ...
rmdopen.bmj

Evaluating the role of lipopolysaccharides in the joint: fibronectin as a novel protective mechanism

Objective To investigate the presence and bioactivity of lipopolysaccharides (LPS) in synovial fluid (SF) of osteoarthritis (OA) patients and elucidate mechanisms modulating their inflammatory ...
rmdopen.bmj

Outcomes of patients with systemic lupus erythematosus treated with belimumab: a post hoc efficacy analysis of five phase III clinical trials by British Isles Lupus Assessment ...

Objectives To determine belimumab efficacy assessed using the British Isles Lupus Assessment Group (BILAG)-based Combined Lupus Assessment (BICLA) in patients with systemic lupus erythematosus (SLE) ...