Understanding the risks associated with healthcare interventions is essential for clinical decision-making and for the regulatory evaluation of new drugs. Yet, safety analyses in randomised controlled ...

Target Trial Emulation (TTE), a framework for improving observational research, is attracting attention and increasingly influencing decision-making.1 Its retrospective nature enables large samples, ...

In clinical research, statistically significant effects do not necessarily indicate that an intervention provides benefits that are meaningful to patients. This is particularly important for ...

The Canadian Task Force on Preventive Health Care’s (CTFPHC) mandate was to develop and disseminate evidence-based clinical practice guidelines to support primary care providers.1 Members were ...

Ethnicity data are essential in understanding how different groups are impacted by different treatments/healthcare interventions, but more work is needed in how these data should be collected, handled ...

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Objectives Probability or risk outcome estimates tailored to individual patient characteristics can facilitate more personalised care, for example, regarding treatment. Yet, the uptake of prediction ...

Early formulations of evidence-based medicine and healthcare emphasised the ability of health professionals to formulate questions, search for and critically appraise individual studies to inform ...

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Jay Pan and colleagues stress that reducing low-value medical services and enhancing healthcare quality must be an urgent priority in China; advancing the Choosing Wisely initiative represents a ...