That the talks are even happening represents a historic moment, given the decades of enmity between the two countries since the 1979 Islamic Revolution and the U.S. Embassy hostage crisis.

ROME—Iran is planning to set out a series of proposals for a new nuclear pact, including guarantees from the Trump administration that the U.S. won’t leave a future accord, people familiar with the matter said,

The United States and Iran are due to hold their second round of nuclear talks on Saturday, as what both sides are looking for in a deal begins to take shape.