A young defense with lots of rookies or first-time starters lost stars Nick Bosa and Fred Warner for the entire season in ...

SANTA CLARA, Calif. — Quarterback Brock Purdy will miss his sixth straight start for the San Francisco 49ers with a toe ...

Injuries are a significant factor in the results of NFL action every week, and that certainly will be the case in Week 10 as ...

The 49ers are preparing for a big divisional clash with the Rams Sunday and Brock Purdy could be active for the first time ...

San Francisco 49ers quarterback Brock Purdy might be back in uniform for the first time in six weeks on Sunday against the ...

The 49ers named Mac Jones as the starter for the sixth consecutive game and the eighth time this season. Starter Brock Purdy ...

While quarterback Brock Purdy slowly works his way back from injury, the 49ers will once again turn to Mac Jones as the ...

The San Francisco 49ers' Week 10 injury report didn't have much good news for a handful of the team's starters.

The San Francisco 49ers will start Mac Jones at quarterback against the Los Angeles Rams on Sunday while Brock Purdy continues to recover from his turf toe injury, according to ESPN's Adam Schefter.

The San Francisco 49ers lost another key defensive player for the season when rookie Mykel Williams went down with a knee ...

Mac Jones will make his sixth straight start in place of Brock Purdy when the 49ers (6-3) host the Los Angeles Rams (6-2) on ...