The Red Sox suffered one of their worst losses of 2025, falling in 11 innings Tuesday despite Nathaniel Lowe's heroics in the ninth.

Here are five things to know as the Red Sox and Yankees begin a key series in the Bronx. Read more on Boston.com.

The Red Sox concocted a plan before their series against the Orioles and stuck to it, manager Alex Cora said after a frustrating 4-3 loss at Fenway Park on Tuesday night.

Boston left the bases loaded in the eighth, ninth and 10th innings Tuesday, squandering crucial opportunities to score.

The Red Sox can't afford to slip up right now, but failed to log a single hit with runners in scoring position in a frustrating loss to the Orioles.

The 21-year-old Orioles star has seen some of the progress Red Sox rookie Kristian Campbell has made since being demoted to Triple-A Worcester.

The final-quarter of the season is not the time to worry about roster flexibility; it could cost the Sox a playoff spot.

The term "gut punch" might be overused on occasion, but it assuredly applied to the Boston Red Sox's 4-3 loss to the Baltimore Orioles on Tuesday night. The Red Sox loaded the bases in the eighth inning with no outs,

Cora made good on that final promise on Monday night, as Lowe came in to pinch-hit in the ninth inning against Baltimore Orioles closer Yennier Cano. He drew a seven-pitch walk and scored on a Jarren Duran double, but Boston still lost 6-3.

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BOSTON — Over the course of a long season, there are often multiple candidates for worst loss of the year. Only a few days ago, the Red Sox squandered a two-run lead with six outs to go. And the fact that they’ve been walked off 11 times on the road is a reminder that there’s plenty of competition for the title.