Over the past decade, several tumor-based predictors of cetuximab efficacy have been identified, yet most function as ...
Elevated WNT signalling triggers a wound-like response in RAS cancer cells, activating TLRs-dependent canonical NF-κB ...
DnaK/DnaJ or Trigger factor and find that chaperone dependence during primary biogenesis in vivo does not track with ...
Amplified by social media, the overwhelmingly positive balance between population benefit and individual damage is forgotten. This has been the case for Covid vaccinations, where politics and health ...
Selective autophagy ensures the targeted degradation of damaged or surplus cellular components, including organelles, thereby ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. ER-phagy, a selective form of autophagic ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Tank-binding kinase 1 (TBK1) is a Ser/Thr ...
Insertion of strongly hydrophobic TMDs into the ER membrane is mediated by the Sec61 complex for co‐translational insertion and the GET complex for post‐translational insertion of tail‐anchors ...
This study introduces a physiological role for brain glucagon action in regulating postprandial glucose homeostasis. Glucagon acts in the DVC to suppress glucose production and to mediate the lowering ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cellular senescence is a form of stable growth ...
The regulation of unfolded protein response (UPR) sensors has been studied for over 20 years, but IRE1β has remained a mystery. IRE1β is highly expressed in goblet cells: specialized epithelial cells ...
Brassinosteroids (BRs) are steroid hormones that are essential for the development of plants. A tight control of BR homeostasis is vital for modulating their impact on growth responses. Although it is ...
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