The big day has finally arrived for Jay and Pamela. Both have a rare genetic disorder called osteogenesis imperfecta type 3 ...

The TLC stars were born with the same rare genetic condition and have broken more than 400 bones between them.

This year, the group is fundraising for Shriners Children's in Greenville, South Carolina.

How a 1981 episode of 'Mister Rogers' Neighborhood' opened kids' eyes to one boy's story — and now inspires a new character ...

Jay & Pamela star Jay Manuel broke down in tears as he reflected on his future with Pamela Chavez, as the couple continues to ...

Her life embodies a paradox: fragility and fortitude intertwined. Each stitch in her embroidery carries the weight of her ...

Jeff Erlanger was a longtime fan of Fred Rogers before appearing on his show, and the two became friends for life ...

Ultragenyx's strong revenue growth, diverse streams, and late-stage pipeline make it a standout in rare disease and gene ...

The first TLC show I started watching was Baylen Out Loud. This series follows 22-year-old Baylen Dupree as she navigates ...

Jay Manuel, 28, and Pamela Chavez, 30, were both born with a rare disorder called Osteogenesis Imperfecta Type III (OI). Combined, they’ve had over 400 fractures, but that’s not slowing them down from ...