Colorectal cancer (CRC) arises from genetic and epigenetic alterations, including histone modifications. Unlike genetic changes, epigenetic alterations are reversible, making them attractive ...

Super-enhancers (SEs) are large clusters of transcriptional regulatory elements that drive oncogene expression, maintain ...

Super-enhancers (SEs) are large clusters of transcriptional regulatory elements that drive oncogene expression, maintain malignancy, and create ...

Researchers have mapped how "histone bivalency" acts as a molecular clock for brain development. By holding genes in a poised state, this mechanism ensures neurons mature only after completing ...

Every cell in your body faces the same engineering puzzle: how to cram roughly two meters of DNA into a nucleus just a few ...

A new review highlights how lactylation—a lactate-induced protein modification—drives lung cancer progression, immune escape, and therapy resistance. It details the “writer-eraser-reader” regulatory ...

Scientists have discovered that increased expression of a novel long non-coding RNA drives glioblastoma cell growth alongside ...

The Damon Runyon Cancer Research Foundation has named 13 new Damon Runyon Fellows, exceptional postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading ...

Researchers have uncovered epigenetic signatures behind persistent cellular memories of inflammation, which can drive chronic inflammatory diseases and cancer.

In the intricate regulation of inflammation, metabolic reprogramming and posttranslational modification (PTM) have emerged as pivotal players, offering new avenues for understanding the fine-tuned ...