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Comparative effectiveness of osteochondral restoration, cell-based regeneration and cell-free implants for knee chondral defects: a systematic review

Objectives Chondral defects of the knee can impair function, reduce quality of life and accelerate progression to osteoarthritis. Treatment aims to delay further cartilage damage and reduce the risk ...
GEN

iPSC-Based Manufacture vs. Autologous Model Production Costs Examined via Financial Analysis

Autologous and allogeneic cell therapies are establishing viable clinical pathways but cannot be manufactured cost-effectively at scale. Manufacturing natural killer (NK) cell therapies, and possibly ...
ascopubs.org

Phase 1/1b study of PRGN-3005 autologous UltraCAR-T cells manufactured overnight for infusion next day to advanced stage platinum resistant ovarian cancer patients.

Predictors of long-term progression-free survival (PFS) in niraparib-treated patients (pts) from the PRIMA/ENGOT-OV26/GOG-3012 study. This is an ASCO Meeting Abstract from the 2023 ASCO Annual Meeting ...
ascopubs.org

A phase 1, first in human study of adenovirally transduced autologous macrophages engineered to contain an anti-HER2 chimeric antigen receptor (CAR) in subjects with HER2 ...

A phase 1/2, open-label, dose-escalation, safety and tolerability study of NC410 in subjects with advanced or metastatic solid tumors. Master protocol to assess safety and recommended phase 2 dose of ...
Nature

A personalized approach to halting kidney disease

A personalized approach to halting kidney disease inRegen’s personalized progenitor cell therapy injects autologous kidney cells (REACT) into patients’ damaged kidneys, where cells migrate and restore ...