Liver fibrosis represents a serious worldwide health issue with a prevalence of around 5% in general populations.1 The most ...
Background The pathogenesis of liver fibrosis centres on the activation of hepatic stellate cells (HSCs). Adenosine-to-inosine RNA editing, primarily catalysed by adenosine deaminase acting on RNA1 ...
2 Department of Clinical Biochemistry, Dalian Medical University, Dalian, China 3 Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, China 4 Institutes ...
Background Alzheimer’s disease (AD) is a neurodegenerative disorder marked by the accumulation of amyloid-β (Aβ) plaques and tau neurofibrillary tangles, leading to cognitive decline. Recent research ...
12 Liver Clinic, Toronto Western & General Hospital, University Health Network, Toronto, Ontario, Canada Correspondence to Professor H L A Janssen, University of Toronto & Erasmus University Rotterdam ...
Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two isoforms (COX-1 and COX-2). COX-1 is constitutively expressed in the gastrointestinal tract in large quantities and ...
1 Department of Virology, Istituto Superiore di Sanità, Rome, Italy 2 Department of Epidemiology, Istituto Superiore di Sanità, Rome, Italy Background: Hepatitis C virus (HCV) infection is common ...
Background:During the process of tumorigenesis most colon cancer cells acquire resistance to apoptosis. The short chain fatty acid butyrate is well established as an antitumour agent which selectively ...
Background and aims Acute-on-chronic liver failure (ACLF) is characterised by acute decompensation of cirrhosis associated with organ failures. We systematically evaluated the geographical variations ...
Background Eosinophilic oesophagitis (EoE) is a chronic allergic disease characterised by oesophageal epithelial remodelling, ...
Objective Postoperative ileus (POI) is assumed to result from myeloid cells infiltrating the intestinal muscularis externa (ME) in patients undergoing abdominal surgery. In the current study, we ...
Background CDH1 is commonly mutated in sporadic diffuse gastric cancer (DGC) and germline CDH1 mutations underlie most cases of the cancer syndrome hereditary DGC. Objective We aimed to develop mouse ...
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