Introduction: EBV-associated nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer that is prevalence in southern China and Southeast Asia. While radiotherapy or concurrent ...

Cyclin E (CCNE1) is amplified in multiple cancers including approximately 10% of esophagogastric cancers and 20% of ovarian cancers. CCNE1 amplification leads to DNA replication stress and chromosomal ...

Cancer Res (2025) 85 (8_Supplement_1): 1160.

Cancer Res (2026) 86 (5_Supplement_2): A010.

Abstract. A key barrier to effective immunotherapy for cancer is the immunosuppressive tumor microenvironment (TME) characterized by infiltrating regulatory T cells (Tregs) and myeloid-derived ...

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Background: KRAS is a key mediator of the RAS/MAPK signaling cascade and promotes cellular growth and proliferation. It is the most frequently mutated oncogene in cancer, and KRAS G12C mutations occur ...

Although T cell–based therapies have shown great promise for treatment of hematologic malignancies, many barriers limit their success in solid tumor types. One such limitation is the scarcity of ...

1Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, ...

Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex Open Access Linjie Yuan; Wenzhi Ji; Brendan G. Dwyer; Joey Lu; Jing Bian; ...

Cancer Res (2019) 79 (13_Supplement): 5017. We previously reported that intratumoral (IT) mouse (m) IL-12 mRNA, the surrogate for MEDI1191, promotes cytotoxic T cell-dependent anti-tumor immunity and ...

Cancer Res (2022) 82 (12_Supplement): 5457. Background: The 3 rd-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), like osimertinib, provide marked clinical benefit ...