Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

The research field of 'cellular IRESes' lay dormant for decades, as there was no uniform standard of reliable methods for the clear characterization of these starting points for the ribosome-mediated ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

What if you could flip a genetic switch to silence a gene, then turn it back on with a simple drug? For researchers, gene-switch tools offer that kind of control—and a new system called Cyclone may ...

This voice experience is generated by AI. Learn more. This voice experience is generated by AI. Learn more. Alternative splicing—the way cells edit gene messages—forms a second, independent layer of ...

Origin-recognition complex, or ORC, plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports. This is the first detailed study ...

Genetic activity underlies biological functions, so organisms have to make sure that the right genes are expressed at the ...

DNA is the blueprint of life. Genes encode proteins and serve as the body's basic components. However, building a functioning organism also requires precise instructions about when, where, and how ...

urning genes on and off is like flipping a light switch, controlling whether genes in a cell are active. When a gene is turned on, the production of proteins or other substances is promoted; when it's ...

On the left is a snapshot of single histone molecules (red) inside a cell nucleus (dotted line). On the right, we see the trajectories of these molecules’ movement over time. The colors show the path ...