Gut

Eosinophilic gastritis: burden of disease, diagnostic challenges and unmet needs

Eosinophilic gastritis (EoG) is a rare, chronic disease characterised by pathological eosinophilia of the stomach and ...
Gut

Hospitalisation in cirrhosis is linked to distinct gut microbiome structural and functional profiles: a multinational metagenomic study

Background Hospitalisations represent major clinical events in cirrhosis, yet prediction based on clinical variables alone ...
Gut

Global epidemiology of disorders of gut–brain interaction: new insights with Rome V

Following publication of the Rome V diagnostic criteria for disorders of gut–brain interaction (DGBI) earlier this year,1 the ...
Gut

Divergent microbial preludes to necrotising enterocolitis defined by gut phages and bacterial resistomes

Background Translating microbiome correlations into robust predictive features for complex gut disorders remains elusive, ...
Gut

A durably colonising engineered native symbiont enables sustained intestinal delivery for metabolic dysfunction and colitis

Background Engineered bacterial therapeutics represent a promising strategy for sustained intestinal delivery of therapeutic ...
Gut

Coordinated cellular programmes distinguish responses to neoadjuvant PD-L1 blockade and potentiate combinatorial immunotherapy in ESCC

Background Programmed death ligand 1 (PD-L1) blockade offers new therapeutic options for oesophageal squamous cell carcinoma ...
gut.bmj

ClC-3 chloride channel/antiporter defect contributes to inflammatory bowel disease in humans and mice

3 Gastrointestinal Institute, the 6th Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China Correspondence to Professor Jia-Guo Zhou, Department of Pharmacology, Zhongshan School of ...
gut.bmj

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gut.bmj

Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease

Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, has multifactorial aetiology with complex interactions between genetic and environmental factors. Over 150 ...
gut.bmj

Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transport

Correspondence to: Dr M Heyman INSERM EMI 0212, Faculté Necker-Enfants Malades, 156 rue de Vaugirard, 75730 Paris, France; heymannecker.fr Background: Probiotic bacteria have a beneficial effect on ...
gut.bmj

Combination of carvedilol with variceal band ligation in prevention of first variceal bleed in Child-Turcotte-Pugh B and C cirrhosis with high-risk oesophageal varices: the ...

Correspondence to Professor Shiv Kumar Sarin, Hepatology, Institute of Liver and Biliary Sciences, New Delhi, Delhi 110070, India; shivsarin{at}gmail.com Objectives Beta-blockers and endoscopic ...
gut.bmj

Cold snare endoscopic resection for large colon polyps: a randomised trial

Background Complications of endoscopic mucosal resection (EMR) of large colorectal polyps remain a concern. Objective We aimed to compare safety and efficacy of cold EMR (without electrocautery) to ...