Gut

Norepinephrine promotes tumour cell aggressiveness and NK cell ferroptosis via ADRB2 in intrahepatic cholangiocarcinoma with perineural invasion

Background Sympathetic signalling plays a critical role in the initiation and progression of various malignancies. However, ...
Gut

Tryptophan depletion generates hyper-reactive portal neutrophils in alcoholic liver disease

Background Neutrophils guarantee a prompt and robust host response to pathogens. Yet, overshooting neutrophil activation ...
Gut

Loss of sinusoidal endothelial identity: RAP1A at the crossroads of capillarisation and liver fibrosis

Liver fibrosis represents a serious worldwide health issue with a prevalence of around 5% in general populations.1 The most ...
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Cholesterol crystallisation in bile

Professor G P vanBerge-Henegouwen, Department of Gastroenterology, University Hospital Utrecht, PO Box 85500, Utrecht, The Netherlands. If you wish to reuse any or ...
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Entecavir treatment does not eliminate the risk of hepatocellular carcinoma in chronic hepatitis B: limited role for risk scores in Caucasians

12 Liver Clinic, Toronto Western & General Hospital, University Health Network, Toronto, Ontario, Canada Correspondence to Professor H L A Janssen, University of Toronto & Erasmus University Rotterdam ...
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Inflammation of the gastro-oesophageal junction (carditis) in patients with symptomatic gastro-oesophageal reflux disease: a prospective study

Department of Medicine, Division of Digestive Diseases and Gastroenterology, UCLA Medical Centre and Beth Israel Deaconess Medical Centre, Los Angeles, California, USA Dr T Lembo, Beth Israel ...
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Integrative proteogenomics maps multifactorial aetiology, progression and therapeutic vulnerabilities in gastric cancer

Background Gastric cancer, with disproportionately higher incidence in East Asia, arises from complex host–microbiome–environment interactions beyond Helicobacter pylori (HP) infection. However, the ...
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Chronic liver disease negatively affects outcome in hospitalised patients with community-acquired pneumonia

We read with great interest the article by Fernández and colleagues1 which identifies bacterial infections, including pneumonia, not only as a trigger, but also as a common complication of ...
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Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer

2 Max Eder Research Group supported by the German Cancer Aid, University Hospital Erlangen, Erlangen, Germany 7 Department of Gastroenterology, Endocrinology and Metabolism, University Hospital of ...
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IDDF2025-ABS-0356 Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocyte and generating quinolinic acid

2 Institute of Digestive Disease and the Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong ...
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Cyclooxygenase 2—implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives

Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two isoforms (COX-1 and COX-2). COX-1 is constitutively expressed in the gastrointestinal tract in large quantities and ...
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Enteroglial-derived S100B protein integrates bacteria-induced Toll-like receptor signalling in human enteric glial cells

3 Department of Experimental Medicine, Biotechnology and Molecular Biology section, Seconda Università di Napoli, Naples, Italy Correspondence to Professor Rosario Cuomo, Department of Clinical and ...