A defining characteristic of cancer cells is their immortality. Usually, normal cells are limited in the number of times they can divide before they stop growing. Cancer cells, however, can overcome ...

Scientists discovered that the protein RPA plays a critical and previously unconfirmed role in stimulating telomerase to ...

A new study led by researchers at the University of Pittsburgh (Pitt) and UPMC Hillman Cancer Center has shown that an enzyme called PARP1 is involved in the repair of telomeres, the lengths of DNA ...

Each human telomere is composed of 10-15 kb of repetitive DNA bound by a protein complex called shelterin, which forms a protective nucleoprotein cap at the chromosome end. In addition to shelterin, ...

Researchers uncover a crucial hidden function of the protein RPA, revealing how its failure to activate telomerase leads to ...

Telomeres, the repetitive sequences of DNA at the ends of linear chromosomes, have an important function: They protect vulnerable chromosome ends from molecular attack. Researchers at Rockefeller ...

New findings describe how the enzyme CST is recruited to the end of the telomere, where it maintains telomere length with the help of subtle chemical changes made to the protein POT1. The length of ...

Loops at the ends of telomeres play a vital protective role preventing irretrievable damage to chromosomes, according to new research from the Crick. The study, published in Nature, showed how the ...

(THE CONVERSATION) A defining characteristic of cancer cells is their immortality. Usually, normal cells are limited in the number of times they can divide before they stop growing. Cancer cells, ...