Glutamate receptors, including AMPA and NMDA subtypes, are pivotal mediators of excitatory transmission and plasticity across the mammalian central nervous system. Their regulation, which involves ...

In a study published in Cell, a research team led by Zhu Shujia from the Center for Excellence in Brain Science and Intelligence Technology of the Chinese Academy of Sciences (CAS), along with Li Yang ...

A new study suggests a potential molecular strategy for treating fragile X syndrome, an inherited neurodevelopmental disorder that causes autism spectrum disorder and intellectual disability. This ...

Observations of the small protrusions that line the dendrites of neurons, called spines, were critical in understanding the function of NMDA receptors in the new study, as well as a precursor to the ...

The links between neurons are crucial to the brain, and brain cells can reorganize the way they are linked together in a phenomenon known as neuroplasticity. This process is ongoing during a lifetime, ...

(a) Diagram illustrating the ion channel activity in post-synaptic neurons. AMPA receptors are involved in the activation of post-synaptic neurons, while NMDA receptors are blocked by magnesium ions ...

Researchers from The University of Texas at Dallas’ Center for Advanced Pain Studies (TX, USA) and their colleagues have made a fundamental discovery about a key mechanism that enables nervous system ...

Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were ...

Researchers headed by a team at the University of Texas at Dallas’ Center for Advanced Pain Studies (CAPS) have made a fundamental discovery about a key mechanism that enables nervous system ...