Another possibility is that the differences in function of myosin IIA and myosin IIB reflect differences in their basic motor properties. Although myosin IIA and myosin IIB share many biochemical ...

Non-muscle myosin II (NM II) is a hexameric actin-binding protein that is formed of two heavy chains, two essential light chains and two regulatory light chains. Its conformation and function are ...

That kind of information should help pharmaceutical companies in the search for drug compounds that can coax malfunctioning myosin in the heart to do its job properly. "Because our novel assay system ...

Boron, though required only in minimal amounts, is vital for plant development. It strengthens cell walls and supports the growth of roots and shoots. Normally, boron, in the form of boric acid, is ...

Hypertrophic cardiomyopathy (HCM) is a common genetic disorder characterized by left ventricular hypertrophy and cardiac hyper-contractility. Mutations in the β cardiac myosin heavy chain gene (β-MyHC ...

Numerous motor and structural proteins compose a highly ordered structure known as the sarcomere, the basic unit of muscle contraction in heart and skeletal muscles. Sarcomeric myosin heavy chain ...

In its early stages, Alzheimer disease is increasingly recognized as a disease of synapses, those key mediators of memory storage in the brain. Enhancing synaptic function, therefore, might be a ...

A University of Massachusetts Amherst kinesiologist has received a five-year, $2 million grant from the National Institutes of Health (NIH) to advance his research on how myosin molecules—molecular ...

Project Summary All cells display some form of polarity which manifests itself in an asymmetric distribution of specific molecules or organelles, yet the mechanisms driving cell polarity remain ...