Researchers have found that the way DNA is packaged in cells can directly impact how fast DNA itself is copied during cell division. They discovered that DNA packaging sends signals through an unusual ...
Each cell in our bodies carries about two meters of DNA in its nucleus, packed into a tiny volume of just a few hundred cubic micrometers—about a millionth of a milliliter. The cell manages this by ...
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The DNA from a single human cell would stretch about two meters if pulled into a line
Stretched into a single line, the DNA packed inside one human cell would reach roughly two meters, yet it folds into a nucleus just 5 to 10 micrometers wide. That compression ratio, on the order of ...
It's a common storytelling trope: the stubborn foe who is eventually revealed to be a much-needed friend. Biology has its own version. Cornell researchers have discovered that DNA packaging structures ...
The paper B.W. Bauer et al., “Cohesin mediates DNA loop extrusion by a ‘swing and clamp’ mechanism,” Cell, 184:5448–64, 2021. Approximately 2 meters of DNA is crammed into each of the human body’s ...
Researchers have used laser-powered ‘optical tweezers’ to reveal a universal motor mechanism used by viruses for packaging their DNA into infectious particles. Researchers have used laser-powered ...
Multi-subunit ring-ATPases carry out a myriad of biological functions, including genome packaging in viruses. Though the basic structures and functions of these motors have been well-established, the ...
Efficient manufacture of recombinant adeno-associated virus (rAAV) vectors for gene therapy remains challenging. Packaging cell lines containing stable integration of the AAV rep/cap genes have been ...
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