DNA replicates once per cell cycle. Interfering with the regulation of DNA replication initiation generates genome instability through over-replication and has been linked to early stages of cancer ...

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published in Nature. Subscribe to our newsletter for the latest sci-tech news updates.

To exclude that enhanced lesion removal might be a consequence of damage dilution due to DNA replication, we performed an EdU-incorporation assay in L1 worms. Both lin-52 mutant and WT worms showed ...