Focal adhesion kinase (FAK) is a central regulator of how cells sense and respond to their surroundings. Situated at integrin-based adhesions, FAK transmits signals from the extracellular matrix and ...

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that orchestrates the dynamic interplay between cells and their extracellular matrix. Localised to multiprotein complexes termed focal ...

Within the past decade, biologists have discovered that one strategy cells use to keep their contents organized is a ...

This graphic illustrates paracrine adhesion signaling on small extracellular vesicles, which secretes a protein called galectin-3, which promotes endocytosis so the vesicle can be absorbed into the ...

P-cadherin is a protein commonly found on malignant cancer cells and has been used as a target for antibody-based cancer treatments. UC Davis biomedical engineers have discovered that when an antibody ...

Breast cancer is the second highest diagnosed cancer in women in the US and, as of 2020, the most commonly diagnosed cancer in women worldwide. 1 In 15–20 percent of these cases, the growth factor ...

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...

We owe a lot to tissue resident memory T cells (T RM). These specialized immune cells are among the body's first responders to disease. Rather than coursing through the bloodstream-as many T cells ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

A new study shows how an anticancer drug triggers an 'outside in' signal that gets it sucked into a cancer cell. The work reveals a new signaling mechanism that could be exploited for delivering other ...