In 2020, Ashley Harms, Ph.D., and University of Alabama at Birmingham colleagues published an Acta Neuropathologica study that used a mouse model to show that the alpha-synuclein pathology from ...

Researchers know that ApoE4 and Trem2 can worsen neurodegeneration in mouse models of tauopathy. Do these proteins conspire to exacerbate pathology? It turns out that ApoE4 causes much of the damage ...

Neurodegeneration results from a number of neurological conditions affecting older adults, including Alzheimer’s disease and Parkinson’s disease. Treating such diseases is challenging enough, but in ...

Autoimmune gastritis is a chronic progressive inflammatory condition that results in the replacement of the parietal cell mass by atrophic and metaplastic mucosa. A complex interaction of ...

In the brains of carriers of familial Alzheimer’s disease mutations, Aβ starts accumulating in some regions more than two decades before symptoms appear, metabolism wanes six years later, and the ...

Distinct retinal vessel atrophy patterns may be associated with multiple sclerosis (MS), but further research is needed to assess retinal vessel changes and their underlying role in MS. Changes in the ...

Brain atrophy (cerebral atrophy) is the loss of brain cells called neurons, as well as the connections that help cells communicate. It can result from different diseases that damage the brain. As you ...

Muscle atrophy is the loss of muscle mass. Low physical activity, nutritional deficiencies, genetic factors, and some medical conditions may contribute. Muscle atrophy due to inactivity can occur if a ...

BIRMINGHAM, Ala. – Multiple system atrophy is a rare and fatal neurodegenerative disease, where insoluble inclusions of the protein alpha-synuclein appear in oligodendrocyte cells of the brain. The ...