The Trump administration is warning Harvard University that it could take over its patents, worth hundreds of millions of dollars, if a review finds the university hasn’t complied with federal law, an escalation of the ongoing negotiations between the White House and America’s oldest university.

The Trump administration is opening a new front in its battle with Harvard University on the issue of patents, marking a new escalation with the elite school that could result in the loss of additional federal funding or intellectual property rights.

In a letter to University President Alan Garber and obtained by Reuters, Commerce Secretary Howard Lutnick accused Harvard of breaching its legal and contractual requirements tied to the research programs and patents.