The Trump administration is warning Harvard University that it could take over its patents, worth hundreds of millions of dollars, if a review finds the university hasn’t complied with federal law, an escalation of the ongoing negotiations between the White House and America’s oldest university.

The Commerce Department is launching an immediate review of the intellectual property Harvard has derived from federally funded research grants.

In a letter to University President Alan Garber and obtained by Reuters, Commerce Secretary Howard Lutnick accused Harvard of breaching its legal and contractual requirements tied to the research programs and patents.