The 49ers are preparing for a big divisional clash with the Rams Sunday and Brock Purdy could be active for the first time since Week 4.

Injuries are a significant factor in the results of NFL action every week, and that certainly will be the case in Week 10 as the 2025 NFL season hits the back nine weeks of the regular season. There are several notable names whose statuses are unknown for this upcoming Week 10 slate,

Brock Purdy hasn't suited up since late September because of a turf toe injury, but San Francisco 49ers head coach Kyle Shanahan said he doesn't expect the injury to keep Purdy out for the rest of the season.

NFL media insider Tom Pelissero reports that San Francisco 49ers quarterback Brock Purdy is listed as questionable for the Week 10 matchup vs. the Los Angeles Rams.

ESPN analyst Dan Orlovsky floated the possibility Brock Purdy may not get his starting job back from Mac Jones once he's healthy.

Brock Purdy remained limited in Thursday’s practice, and his Week 10 status remains uncertain. The 49ers quarterback, though, is doing more and getting closer.

Saquon Barkley returned to practice with the Philadelphia Eagles after suffering a groin injury against the New York Giants in Week 8. Barkley sat out the remainder of that game as a precaution and had an extra week of rest with the Eagles on a bye last week.

The San Francisco 49ers announced a practice decision regarding quarterback Brock Purdy as the team prepares for Week 10.