Underscoring the entire schedule is that the 2025 campaign will be the last in their longtime home of Highmark Stadium, where they began playing in 1973. As their new stadium across the street is scheduled to be ready for the 2026 season, the Bills have one final chance to chase Super Bowl glory in their farewell season to their 53-year home.

Buffalo Bills schedule is out! Check out the full list of games and projected win-loss record for the upcoming NFL season.

Lost in the shuffle of the Buffalo Bills’ 2025 regular-season schedule release was the news about the upcoming preseason. Admittedly, preseason football is the opposite of exciting, serving as a warm-up for all parties involved.